Important Safety Information for Sildenafil

What is the FDA-approved use of sildenafil?
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED). Your Ro-affiliated provider may prescribe EnduraPulse PeakRise DuoVive, which contains both sildenafil 55 mg and tadalafil 22 mg, as a compounded drug to treat erectile dysfunction.

What is the FDA-approved use of sildenafil?
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED). Your Ro-affiliated provider may prescribe EnduraPulse PeakRise DuoVive, which contains both sildenafil 55 mg and tadalafil 22 mg, as a compounded drug to treat erectile dysfunction.

How should I take EnduraPulse PeakRise DuoVive?

• Place the lozenge under your tongue and let it dissolve. Take at least 15 minutes before sexual activity.

• Do not chew the medication. Once partially dissolved, you may split it for faster melting.

• Requires sexual arousal to work. Avoid eating/drinking while the lozenge dissolves.

• Do not take more than once daily or within 24 hours of other ED medications (tadalafil/sildenafil).

• Test the medication privately first to understand its effects.

Key Benefits of EnduraPulse PeakRise DuoVive

1. Dual-Action Formula for Enhanced Efficacy

• Sildenafil (55 mg): Rapid-onset PDE5 inhibitor designed to improve blood flow to the penile tissue, supporting erectile function within 15–30 minutes.

• Tadalafil (22 mg): Long-acting PDE5 inhibitor providing sustained effects for up to 36 hours, allowing greater spontaneity in intimate moments.

2. Relief for Benign Prostatic Hyperplasia (BPH)

• Tadalafil’s FDA-Approved Benefit: The tadalafil component is clinically proven to alleviate lower urinary tract symptoms (LUTS) associated with BPH, including:

• Reduced urinary frequency and urgency.

• Improved bladder emptying and decreased nighttime awakenings.

• Mechanism: Relaxation of smooth muscle in the prostate and bladder.

3. Synergistic Cardiovascular Support

• Both components may improve endothelial function, potentially benefiting men with mild hypertension or metabolic syndrome (consult a physician for cardiovascular risk assessment).

4. Flexible Dosing for Individual Needs

• Sublingual lozenge format allows faster absorption than traditional oral tablets.

• Combines short-acting and long-acting agents for tailored response timing.

5. Improved Quality of Life

• Addresses both ED and BPH symptoms in a single medication, reducing the need for multiple prescriptions.

• May enhance confidence, intimacy, and overall well-being.